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  • Title: Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.
    Author: Adams PR, Harrison R.
    Journal: Biochem J; 1974 Sep; 141(3):729-32. PubMed ID: 4463960.
    Abstract:
    S-(+)-3,4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-phosphate, was synthesized stereospecifically and shown to be an effective substrate for rabbit muscle glycerol 3-phosphate dehydrogenase (sn-glycerol 3-phosphate-NAD(+) oxidoreductase, EC 1.1.1.8). Non-isosteric phosphonate analogues of sn-glycerol 3-phosphate showed neither substrate nor inhibitory activity with the enzyme.
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