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  • Title: Murine primitive neuroectodermal tumor: nucleolar isolation and RNA polymerase inhibition.
    Author: Slagel DE, Kauffman W.
    Journal: Experientia; 1979 May 15; 35(5):660-2. PubMed ID: 446675.
    Abstract:
    A nucleolar isolation procedure was developed for the murine primitive neuroectodermal tumor originally induced with methylcholanthrene. This procedure utilizes sonication for breakage of the nuclei at a magnesium concentration which disperses the extranucleolar chromatin. The nucleoli retain RNA synthetic activity which is inhibited to about 90% by actinomycin D and the chemotherapeutic drug adriamycin.
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