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  • Title: [Hypervitaminosis A and the state of the chromosome apparatus of the rat bone marrow cells].
    Author: Aldabergenova KU, Kuzdenbaeva RS, Bigaliev AB.
    Journal: Farmakol Toksikol; 1979; 42(3):278-81. PubMed ID: 446710.
    Abstract:
    In experiments on rats overdoses of vitamin A produced an increased frequency of cells with chromosomal aberrations and elevated number of polyploid cells. Still more pronounced disturbances were recorded in the structure and ploidity of chromosomes if hypervitaminosis A was accompanied by deficient protein nutrition.
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