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  • Title: Electrophoretic variant of fetal intestinal alkaline phosphatase in a patient with cirrhotic liver.
    Author: Kudo S, Higashino K, Yamamura Y.
    Journal: Gan; 1979 Feb; 70(1):15-9. PubMed ID: 446973.
    Abstract:
    Alkaline phosphatases, which had a unique electrophoretic mobility on polyacrylamide gel electrophoresis, were found in hepatic tissue of a patient with liver cirrhosis. Enzymic and immunological properties of the enzymes examined on electropherogram were similar to those of a fetal intestinal-type alkaline phosphatase in hepatoma with respect to sensitivity to amino acids, heat stability, sensitivity to sodium dodecyl sulfate, and reactivity to anti-intestinal alkaline phosphatase antiserum. The enzymes seem to be a variant of a fetal intestinal alkaline phosphatase. The significance of occurrence of the enzymes in cirrhotic liver is discussed.
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