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  • Title: Effect of Nocardia rubra cell-wall skeleton on the induction of lung cancer in ACI/N rats.
    Author: Namba M, Yoshimoto T, Ogura T, Hirao F, Azuma I, Yamamura Y.
    Journal: Gan; 1979 Feb; 70(1):55-62. PubMed ID: 446976.
    Abstract:
    Administration of oil-attached Nocardia rubra cell-wall skeleton (N. rubra-CWS) was evaluated for the effect of the induction of lung cancers in ACI/N rats. Lung cancers were induced by 15 weekly intratracheal instillations of 3 mg benzo[a]-pyrene with 3 mg ferric oxide. After the 10th instillation of the carcinogen, rats received seven subcutaneous injections of 100 microgram of N. rubra-CWS at 2-week intervals. In the observation period of 56 weeks, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.
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