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  • Title: Comparative assay of HCG, HCT and HCS in molar pregnancy.
    Author: Tojo S, Mochizuki M, Kanazawa S.
    Journal: Acta Obstet Gynecol Scand; 1974; 53(4):369-73. PubMed ID: 4474790.
    Abstract:
    The secretion patterns of human chorionic gonadotropin (HCG), human chorionic somatomammotropin (HCS), and human chorionic thyrotropin (HCT) were studied in 10 women with hydatidiform mole and 30 women in the early stage of normal pregnancy. Serum levels of the chorionic hormones were determined by radioimmunoassay with the double-antibody method. In the cases of hydatidiform mole, HCG and HCT levels were considerably higher than values normally obtained during pregnancy, while HCS levels were abnormally low. HCG and HCT levels did not change 6 hours after molar delivery, though HCS levels rapidly decreased and became undetectable shortly thereafter. It required 3 weeks for HCG to fall to the level of pituitary luteinizing hormone and 5 days for HCT to become undetectable. The observed differences are regarded as characteristic findings in hydatidiform mole. It was concluded that simultaneous assay of HCG, HCT, and HCS is a useful indicator of the completeness of treatment of hydatidiform mole.
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