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  • Title: Effect of temperature on changes, induced by oestrus, in alpha- and beta-adrenoceptor activities of the rat uterus.
    Author: Butterworth KR, Jarman DA.
    Journal: Br J Pharmacol; 1974 Jul; 51(3):462-4. PubMed ID: 4476226.
    Abstract:
    The alpha- and beta-adrenoceptor activities of the isolated rat uterus during the oestrous cycle were intluenced greatly by temperature changes. During dioestrus, lowering the bath temperature to 25 degrees C from 40 degrees C increased two-fold the inhibition produced by (-)-adrenaline, (-)-noradrenaline, (-)-phenylephrine and (-)-isoprenaline. During oestrus adrenaline, noradrenaline and phenylephrine produced biphasic responses of contraction followed by inhibition at 40 degrees C and isoprenaline produced only inhibition. At 25 degrees C the contractile alpha-responses either were abolished (phenylephrine) or greatly reduced (adrenaline and noradrenaline), while the inhibitory beta-effects of all four amines were increased.
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