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  • Title: Effect of DDS on phytohemagglutinin-induced lymphocyte transformation.
    Author: Beiguelman B, Pisam RC.
    Journal: Int J Lepr Other Mycobact Dis; 1974; 42(4):412-15. PubMed ID: 4477565.
    Abstract:
    The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals. In one sample the sulfone-treated cultures differed from the controls in that they contained 0.4 mug/ml of other sample, the treated cultures contained DDS in concentrations of 4 mug/ml, 8 mug/ml and 16 mug/ml. The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used. The data obtained are a strong indication that the plasma levels of dapsone among leprosy patients may contribute to the depression of the blastogenic capacity of their lymphocytes when stimulated by PHA.
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