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  • Title: The effect of oestrogen administration on plasma testosterone, FSH and LH levels in patients with Klinefelter's syndrome and normal men.
    Author: Smals AG, Kloppenborg PW, Lequin RM, Benraad TJ.
    Journal: Acta Endocrinol (Copenh); 1974 Dec; 77(4):765-83. PubMed ID: 4479709.
    Abstract:
    The effect of varying doses of ethinyl estradiol (15, 30, and 150 mcg/day for 7 days) on plasma testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) was evaluated in 6 patients (ages 18-38) with Klinefelter's syndrome and compared with the results obtained in 6 eugonadal males (ages 26-41). Mean pretreatment testosterone levels in the Klinefelter patients were significantly (p less than .05) lower than in the eugonadal patients, whereas LH and FSH levels in the Klinefelter patients were significantly higher (p less than .05). 3 of the Klinefelter patients had normal testosterone levels and elevated FSH and LH levels. A dose-dependent decrease of FSH and testosterone followed the estrogen administration in all subjects, whereas the LH decrease was only dose-dependent in the Klinefelter patients. Despite a significant testosterone decrease (p less than .05) after 30 and 150 mcg estrogen, LH and FSH in the Klinefelter patients remained supranormal. 15 mcg decreased LH and testosterone in normal males but not in Klinefelter patients. When human chorionic gonadotropin (HCG) was administered after 150 mcg estrogen/day for 7 days, testosterone decreased in the controls from 522 ng% to 111 ng% and in the Klinefelter patients from 324 to 141 ng%. It is concluded that small amounts of estrogens play a role in the pituitary-gonadal axis in normal males. In Klinefelter's syndrome the hypothalamic-pituitary-gonadal feedback is operative at a higher setting, comparable with that found in eugonadal males.
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