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  • Title: Studies on the terminal stages of immune hemolysis. IV. Effect of metal salts.
    Author: Boyle MD, Langone JJ, Borsos T.
    Journal: J Immunol; 1979 Apr; 122(4):1209-13. PubMed ID: 448086.
    Abstract:
    The inhibitory effect of metal salts on the formation and transformation of E to ghosts was studied. Ferrous and ferric salts inhibited the binding of C9 to EAC1-8 cells but had no other inhibitory role in the reaction. Uranly, copper, and zinc salts inhibited the transformation of the EAC1-9inserted intermediate to E ghosts. This inhibition occurred at a stage prior to detectable damage as measured by 86Rb or hemoglobin release and at a step prior to that inhibitable by high molarity EDTA. Consequently a further step in the reaction sequence of E to ghosts was identified. The reaction sequence leading from EAC1-9 to ghosts can be summarized as follows: formula: (see text).
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