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  • Title: Inhibition of aflatoxin B1-induced cytotoxicity and binding to DNA in cultured rat liver cells by naturally occurring flavones.
    Author: Schwartz AG, Rate WR.
    Journal: J Environ Pathol Toxicol; 1979; 2(4):1021-8. PubMed ID: 448249.
    Abstract:
    For naturally occurring flavones, quercetin, fisetin, nobiletin, and tangeritin, protect cultured rat liver epithelial-like cells against aflatoxin B1-induced cytotoxicity and inhibit the binding of [3H] aflatoxin B1 to cellular DNA. The methoxy-substituted flavones, nobiletin and tangeritin, show greater protection against cytotoxicity than do the hydroxy-substituted compounds, quercetin and fisetin.
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