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  • Title: Negative effects of oral fatty acid supplementation on sweat chloride in cystic fibrosis.
    Author: Lloyd-Still JD, Simon SH, Wessel HU, Gibson LE.
    Journal: Pediatrics; 1979 Jul; 64(1):50-2. PubMed ID: 450561.
    Abstract:
    Essential fatty acid supplementation with oral safflower oil (1 gm/kg/day) to 11 cystic fibrosis patients (aged 6 months to 14 years) for one year produced no significant change in sweat chloride concentration (mEq/liter) or sweat rate (gm/min/m2), Addition of vitamin E (10 mg/kg/day) to the safflower oil had no effect on sweat chloride concentration or rate compared to placebo. No clinical improvement could be detected compared to a control group. These results do not support previous reports of the effects of fatty acid supplementation on sweat electrolyte concentrations in cystic fibrosis.
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