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  • Title: Pitfalls in the diagnosis of jaundice due to carcinoma of the pancreas or biliary tree.
    Author: Stern RB, Knill-Jones RP, Williams R.
    Journal: Br Med J; 1973 Mar 03; 1(5852):533-4. PubMed ID: 4511875.
    Abstract:
    Analysis of 56 patients with obstructive jaundice due to carcinoma of the pancreas or extrahepatic biliary tree showed that unexpected features were present in 25%. Presentation with painless jaundice was uncommon, and the symptoms were more often non-specific, with malaise, anorexia, and vomiting. Abdominal pain was frequent, and the condition was found in young patients. One-fifth presented with serum alkaline phosphatase levels of less than 30 K.A. units. Some had high serum aspartate aminotransferase levels, more characteristic of hepatocellular jaundice. A mathematical model may be helpful in correctly weighting these various criteria.
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