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  • Title: Hemoglobin abnormalities in neoplastic hematological disorders.
    Author: Walker IR, Ali MA.
    Journal: Can Med Assoc J; 1973 Apr 07; 108(7):843-7. PubMed ID: 4513360.
    Abstract:
    Fetal hemoglobin (F) and hemoglobin A(2) were estimated in 35 patients with malignant hematological disorders. In 9 out of 10 patients with morphological and cytochemical features of acute myeloblastic leukemia the hemoglobin F was greater than 2%. Of the other 25 patients investigated only one patient with polycythemia rubra vera had a hemoglobin F level of more than 2%. Estimation of fetal hemoglobin may be of value in the classification of acute leukemias and the increased level observed probably reflects disturbed hemoglobin synthesis in the acute myeloblastic type.
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