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  • Title: Effects of ciguatoxin and maitotoxin on the isolated guinea pig atria.
    Author: Miyahara JT, Akau CK, Yasumoto T.
    Journal: Res Commun Chem Pathol Pharmacol; 1979 Jul; 25(1):177-80. PubMed ID: 451353.
    Abstract:
    The effects of ciguatoxin (CT) and maitotoxin (MT) were studied on the isolated atria of the guinea pig. Application of CT evoked a prolonged positive inotropic effect on the electrically-driven atria and both inotropic and chronotropic effects on the spontaneously-beating right atria. The response to MT in contrast was biphasic. At low concentration (10(-8) Gm per ml) MT enhanced the atrial contractility, while at higher concentrations (5 x 10(-8) Gm per ml) it depressed the atria and frequently to a standstill. The results indicate that CT and MT have a direct action on the contractile mechanism of the heart and their effects are readily distinguishable.
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