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  • Title: [Malignat non-Hodgkin Lymphoma in childhood. Therapeutic results in 47 patients].
    Author: Wagner HP, Feldges A, Imbach P, Plüss HJ, Sartorius J, Wyss M.
    Journal: Schweiz Med Wochenschr; 1979 May 26; 109(21):797-801. PubMed ID: 451507.
    Abstract:
    A preliminary report is presented on survival in 16 children with non-Hodgkin's lymphoma treated since 1975, as compared with that in 31 similar children treated between 1962 and 1974. In the former group, 10 of 14 children (71%) survived one or more years and 5 of 9 children (56%) two or more years with no evidence of disease. In the latter group, the corresponding survival rates were 26% and 19% respectively. This improvement is due to the introduction of an aggressive multidrug chemotherapy combined with radiotherapy, similar to the LSA2-L2 protocol. Considerable toxicity was observed with the new treatment. 23 of the 46 patients with diffuse non-Hodgkin's lymphoma had a Burkitt-type tumor. Treatment failures occurred mainly in children with a Burkitt-type tumor with primary intraabdominal localization.
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