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  • Title: Sensitization in Aplysia: restoration of transmission in synapses inactivated by long-term habituation.
    Author: Carew T, Castellucci VF, Kandel ER.
    Journal: Science; 1979 Jul 27; 205(4404):417-9. PubMed ID: 451611.
    Abstract:
    Long-term habituation of a simple withdrawal reflex in Aplysia leads to an inactivation of synaptic transmission between identified sensory and gill motor neurons that persists for more than 3 weeks. A single sensitizing stimulus rapidly reactivates both the depressed behavioral response and the inactivated synaptic transmission. Thus sensitization, a simple competitive form of learning, provides a mechanism whereby changing environmental demands can rapidly override the long-term memory of habituation.
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