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  • Title: Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel.
    Author: Dudai Y, Herzberg M, Silman I.
    Journal: Proc Natl Acad Sci U S A; 1973 Sep; 70(9):2473-6. PubMed ID: 4517659.
    Abstract:
    Three purified molecular forms of acetylcholinesterase (EC 3.1.1.7) with sedimentation coefficients of 18 S, 14 S, and 11 S were studied by analytical ultracentrifugation and electron microscopy. The three species have molecular weights of (1.1 +/- 0.1) x 10(6), (7.5 +/- 1.5) x 10(5), and (3.35 +/- 0.25) x 10(5), respectively. Electron micrographs reveal that the 18S and 14S forms are asymmetric, composed of a head, containing a large number of subunits, and an elongated tail. The 11S form of acetylcholinesterase is apparently a tetrameric structure devoid of the tail. Maleylation of 18S and 14S acetylcholinesterases abolishes their tendency to aggregate at low ionic strength.
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