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  • Title: Maximal concanavalin A-specific agglutinability without loss of density-dependent growth control.
    Author: Glynn RD, Thrash CR, Cunningham DD.
    Journal: Proc Natl Acad Sci U S A; 1973 Sep; 70(9):2676-7. PubMed ID: 4517678.
    Abstract:
    Density-inhibited 3T3 mouse fibroblasts were treated for 10 min with nine concentrations of Pronase ranging from 0.25 to 40 mug/ml. Concanavalin A-specific agglutinability increased from control values of about 25% to plateau values of about 80%. None of these Pronase concentrations brought about an increase in cell number within 84 hr. Pronase-treated cells remained responsive to growth stimulation by serum and cortisol. Therefore, the protease-mediated surface change measured by increased concanavalin A-specific agglutinability is not an event sufficient by itself to bring about cell division.
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