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  • Title: Collagen synthesis: a disulfide-linked collagen precursor in chick bone.
    Author: Fessler LI, Burgeson RE, Morris NP, Fessler JH.
    Journal: Proc Natl Acad Sci U S A; 1973 Oct; 70(10):2993-6. PubMed ID: 4517950.
    Abstract:
    Chick calvaria labeled in vitro contain a triple-stranded collagen precursor that contains two pro alpha1 and one pro alpha2 chains. All chains contain cystine and are linked by S-S bonds. Ultracentrifugal analysis was used to measure the relative size of the disulfide-linked units. It is proposed that the S-S links help to determine the correct alignment of the triple-stranded structure.
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