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  • Title: Sodium uptake associated with activation of action potential ionophores of cultured neuroblastoma and muscle cells.
    Author: Catterall WA, Nirenberg M.
    Journal: Proc Natl Acad Sci U S A; 1973 Dec; 70(12):3759-63. PubMed ID: 4521201.
    Abstract:
    Veratridine, an activator of action potential Na(+) ionophores, stimulated passive Na(+) uptake by electrically excitable neuroblastoma and muscle cells but had no effect on clonal cell lines defective in Na(+)-ionophore activity. Veratridine-dependent Na(+) uptake was completely inhibited by tetrodotoxin, a specific inhibitor of the action potential Na(+) ionophore. Half-maximal inhibition was obtained with 11 nM tetrodotoxin. Thus, veratridinedependent Na(+) uptake provides a specific and convenient means of assaying populations of cultured cells for action potential Na(+)-ionophore activity.
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