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  • Title: [Effect of vitamins on permeability of cells, mitochondria and lysosomes under conditions of graviation overloading].
    Author: Totskii VN.
    Journal: Ukr Biokhim Zh (1978); 1979; 51(2):139-46. PubMed ID: 452128.
    Abstract:
    The gravitaiton overloading causes in experimental animals a decrease in stability of erythrocytes to NaCl hypotonic solutions and liver mitochondria to the effect of triton X=100. Under these conditions permeability of erythrocytes and leucocytes membranes as well as of the liver and brain mitochondria increases for [14C] nicotinate, [35S] lipoate, riboflavin and flavin mononucleotide, the total activity and the activity of the unprecipitable protinase of the liver cell lysosomas rise. Hydrocortisone, pyruvate, ATP, water- and fatty-soluble vitamins in the in vivo and in vitro experiments weaken the effect of overloading on the stability and permeability of the structures under study. Vitamin E applied separately and in combination with vitamin B, flavin mononucleotide and nicotinamide is more effective in this respect.
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