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  • Title: [Activity of Krebs cycle oxidative enzymes in the brain in hypothermia].
    Author: Volzhina-Atabegova NG.
    Journal: Vopr Med Khim; 1979; 25(3):308-11. PubMed ID: 452497.
    Abstract:
    Cooling of rats down to the rectal temperature of 33--35 degrees without the use of narcotic and neuroplegic drugs did not cause distinct alterations in activity of the oxidative enzymes of tricarboxylic acid cycle--isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, malate-, succinate- and pyruvate dehydrogenases in brain tissue. At the same time, inhibition of the activity of these dehydrogenases occurred in profound hypothermia (cooling to 19--20 degrees). In this case the activity of succinate dehydrogenase was decreased less distinctly as compared with the activity of NAD-dependent dehydrogenases. Succinic acid appears to be an especially important substrate for oxidation in brain of the chilled rats.
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