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  • Title: Aminomethyl derivatives of 1-cyclohexyl-5-alkyl- and 1-cyclohexyl-5,5-dialkylbarbituric acids as potential antiinflammatory agents.
    Author: Sladowska H.
    Journal: Farmaco Sci; 1979 Nov; 34(11):979-86. PubMed ID: 45267.
    Abstract:
    The synthesis and the structure of some aminomethyl derivatives of 1-cyclohexylbarbituric acids, obtained by the Mannich reaction, are described. Acids, containing a pyrrolidinomethyl group in the position 5 were found to have the barbituric ring in the enolic form, stabilized by a hydrogen bond with the pyrrolidine nitrogen atom. Some of the described compounds displayed antiinflammatory activity.
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