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  • Title: [Pathologic neutrophilia in acute leukemia].
    Author: Anatkov A, Dobreva A, Noev K, Meshkov T, Velizarova K.
    Journal: Vutr Boles; 1974; 13(6):93-100. PubMed ID: 4534027.
    Abstract:
    The morphological hemogram peculiarities are described in 10 patients with acute leukosis (nine with myeloblastoid variance and one with monocytoid variance of acute leukosis). Leukemic hiatus is not to be found in all the patients and besides paramyeloblasts--granular "filamented neutrophils" are present in the peripheral blood in considerable absolute values. Cytomorphologic, cytochemical and electron microscopic investigations were carried out on those "paraneutophils". Complex data for pathological leukosis characteristics of those cells were established that differed them from the normal cells. In five of the patients--definite data for acute leukosis were obtained with the histomorphological investigation of the blood tissue, in that way excluding primary myeloblast phase of myeloleukosis. Conclusions were drawn that those cells ("paraneutrophils") have the same prognostic value in peripheral blood as paramyeloblasts and are not affected by polychemical therapy. This was stressed to be a more particular variance of acute leukosis.
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