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  • Title: Topical tretinoin therapy and oral lichen planus.
    Author: Sloberg K, Hersle K, Mobacken H, Thilander H.
    Journal: Arch Dermatol; 1979 Jun; 115(6):716-8. PubMed ID: 453874.
    Abstract:
    The treatment of severe forms of oral lichen planus is still relatively unsatisfactory. In this controlled study, 0.1% tretinoin in an adhesive base was used in 23 patients. Fifteen other control patients were similarly treated with the vehicle alone. In the tretinoin-treated group, 71% of the atrophic-erosive lesions improved while 29% improved from the vehicle (P less than .05). Reticular-plaque lesions improved in 74% from tretinoin and in 15% from the vehicle (P less than .001). Irritation from tretinoin occurs and thorough usage information is mandatory.
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