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  • Title: [Electron microscopic study of the characteristics of skeletogenic tissue differentiation during distraction osteosynthesis].
    Author: Mikhaĭlova LN, Shtin VP.
    Journal: Arkh Patol; 1979; 41(5):55-64. PubMed ID: 454229.
    Abstract:
    Electron microscopic examination of the regenerating tissue was performed after distractional osteosynthesis carried out by the method of G. A. Ilizarov. The results showed osteogenesis to occur on the basis of the fibrous tissue formed in diastasis. The observed zones of the regeneration typical of distractional osteosynthesis are due to functional stimulation (tension) resulting in the arrangement of collagen fiber bundles and bone trabeculae in the direction of the extension forces. Cells of the skeletogenic tissue, between the bone fragments are also arranged with their longitudinal axis along the collagen fibril bundles. The ultrastructural pattern of the osteogenesis after distractional osteosynthesis reflects the intensification of the synthesis of glycosaminoglycan-protein complexes forming the main substance of the bone tissue.
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