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  • Title: Contact sensitivity in the mouse. XI. Movement of T blasts in the draining lymph nodes to sites of inflammation.
    Author: Asherson GL, Allwood GG, Mayhew B.
    Journal: Immunology; 1973 Sep; 25(3):485-94. PubMed ID: 4542648.
    Abstract:
    An earlier paper showed that 4 days after immunization with the contact sensitizing agent `oxazolone' there is a peak in the percentage of cells in the draining lymph nodes that move to sites of inflammation. This was assessed by dissociating the lymph nodes, labelling them with 51Cr and injecting them into mice whose ears were painted within an hour with an unrelated contact sensitizing agent or with croton oil. The ears were then removed at about 18 hours and their radioactivity used as a measure of cell arrival. The cells that move to sites of inflammation are not macrophages as they are not removed by filtration through cotton wool. They are θ-positive and control studies show that the activity of the anti-θ serum was indeed due to antibody to the θ-antigen. The cells are large and can be labelled both in vivo and in vitro with [125I]-iododeoxyuridine which is incorporated the DNA of cells during the S phase of the cell mitotic cycle. It was concluded that the cells in immunized lymph nodes that move to sites of inflammation are T blasts. The unitary hypothesis is put forward that following immunization for delayed hypersensitivity a particular class of T cells proliferates and gives rise to large pyroninophilic blast cells; and that these cells or their immediate descendants possess the properties, either at the same time or at closely related times, of movement to sites of inflammation and non-specific cytotoxicity as well as the capacity to passively transfer cellular immunity.
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