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  • Title: Factor VIII coagulant activity and factor VIII-like antigen: independent molecular entities.
    Author: Zimmerman TS, Edgington TS.
    Journal: J Exp Med; 1973 Oct 01; 138(4):1015-20. PubMed ID: 4542733.
    Abstract:
    Factor VIII coagulant activity (VIII(C)) and the von Willebrand's disease antigen (Factor VIII-like antigen, vW-Ag) are biologically linked, and it has been suggested that they reside on the same molecule. However, insolubilized human isoantibody to VIII(C) and rabbit antiserum containing antibodies to VIII(C) and vW-Ag differentially bind and remove these entities from plasma, thus physically segregating one from the other. These findings indicate that Factor VIII coagulant activity resides on a molecule distinct from that expressing the von Willebrand's antigen.
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