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  • Title: The presence of the Lucké herpesvirus genome in induced tadpole tumors and its oncogenicity: Koch-Henle postulates fulfilled.
    Author: Naegele RF, Granoff A, Darlington RW.
    Journal: Proc Natl Acad Sci U S A; 1974 Mar; 71(3):830-4. PubMed ID: 4545010.
    Abstract:
    Herpesvirus extracted from a naturally occurring frog renal carcinoma (Lucké tumor) induced virus-free Lucké tumors in developing frogs. Herpesvirus recovered from an induced tumor after incubation at low temperature of tumor fragments cultured in vitro was oncogenic when injected into developing frog embryos. With the exception of the "pure culture" requirement, this experiment fulfills Koch-Henle postulates for the identification of the causative agent of the Lucké tumor.
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