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  • Title: Germinal centres and the origin of the B-cell system. I. Germinal centres in the rabbit appendix.
    Author: Nieuwenhuis P, van Nouhuijs CE, Eggens JH, Keuning FJ.
    Journal: Immunology; 1974 Mar; 26(3):497-507. PubMed ID: 4546813.
    Abstract:
    Regeneration of follicular structures in the rabbit spleen after a single dose of 450 rads whole body X-irradiation was shown to be dependent upon the presence of the appendix. Results obtained were in favour of a stream of cells—probably derived from appendix germinal centres—to follicular structures in the spleen, in particular to the lymphocyte corona and marginal zone but excluding germinal centres. Recovery of the antibody forming potential following X-irradiation was equally shown to be dependent upon the presence of the appendix. It was concluded that following 450 rads whole body X-irradiation the appendix contributes to the recovery of the antibody forming capacity of the spleen by the production of antibody-forming cell precursors; these latter cells are presumably identical with the follicle replenishing class of lymphocytes derived from appendix germinal centres.
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