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  • Title: The effect of age on the fibrinolytic enzyme system.
    Author: Hamilton PJ, Dawson AA, Ogston D, Douglas AS.
    Journal: J Clin Pathol; 1974 Apr; 27(4):326-9. PubMed ID: 4546946.
    Abstract:
    Components of the fibrinolytic enzyme system, FR-antigen and fibrinogen, were measured in 20 healthy volunteers aged 20-40 years and in 61 elderly subjects aged 66-96 years. Plasminogen activator levels did not significantly differ between the 20-40 and 66-75 age groups, but were higher in those over 75. Plasminogen showed no change with age except for a fall in those over 75. Fibrinogen, FR-antigen, alpha(1)-antitrypsin, and alpha(2)-macroglobulin all rose with age, but the mean fibrinogen concentration fell in the very elderly.
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