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  • Title: [Mechanisms of liver transketolase activation in B1-deficient rats after administration of thiamine].
    Author: Vinogradov VV, Mandrik KA, Strumilo SA, Matsiuk SK.
    Journal: Biokhimiia; 1979 May; 44(5):868-75. PubMed ID: 454716.
    Abstract:
    Gel filtration and equilibrium dialysis demonstrated that the hyaloplasmic fraction of the liver of B1-deficient rats does not practically bind C-TDP in vitro. An addition of the excess of non-labelled coenzyme does not increase the transketolase activity. The data obtained suggest that transketolase activation in the hyaloplasmic fraction of the liver of B1-deficient rats after administration of thiamine in vivo is due to stimulation of the additional synthesis of the enzyme protein rather than to the saturation of the free apoenzyme with newly-formed TDP. In vivo and in vitro studies suggest that the hyaloplasmic fraction of the liver of B1-deficient rats contains no free apoenzyme of transketolase.
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