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  • Title: [Effects of alpha-tocopherol derivatives on natural quinone levels in the tissues of vitamin E deficient rats].
    Author: Donchenko GV, Kovalenko VN, Zabarnaia EN, Makovetskiĭ VP, Basalkevich ED.
    Journal: Biokhimiia; 1979 May; 44(5):923-30. PubMed ID: 454720.
    Abstract:
    The effects of alpha-tocopherol and its derivatives (alpha-tocopherylquinone, its short-chained analog--alpha-tocopheronolactone--and short-chained alpha-tocopherylacetate) on the levels of ubiquinone, its cyclic isomer--ubichromenol--and vitamin E in the liver and heart of vitamin E-deficient rats were studied. After injection of alpha-tocopherol derivatives the levels of ubichromenol and ubiquinone in rat liver and heart were increased, while their ratio was decreased. alpha-Tocopheronolactone was found to exert the strongest action, which is probably due to its direct effect on ubiquinone metabolism in rat tissues.
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