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  • Title: An inhibitory protein of Escherichia coli RNA polymerase in bacteriophage T3-infected cells (core polymerase-sigma factor-host polymerase-phage polymerase-initiation).
    Author: Mahadik SP, Dharmgrongartama B, Srinivasan PR.
    Journal: Proc Natl Acad Sci U S A; 1972 Jan; 69(1):162-6. PubMed ID: 4550502.
    Abstract:
    A partially purified protein isolated from bacteriophage T3-infected cells of Escherichia coli B markedly inhibits the activity of E. coli RNA polymerase, slightly inhibits the activity of purified T3 polymerase, and does not inhibit the activity of either core polymerase or the ribosome-bound T3 polymerase. The properties of this protein and its mechanism of action have been studied. It appears to antagonize the action of the sigma factor component of RNA polymerase.
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