These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A.
    Author: Yahara I, Edelman GM.
    Journal: Proc Natl Acad Sci U S A; 1972 Mar; 69(3):608-12. PubMed ID: 4551979.
    Abstract:
    The induction by anti-immunoglobulin of patch and cap formation on mouse lymphocytes was inhibited by the addition of concanavalin A. This effect was reversed by alpha-methyl-D-mannoside, a competitive inhibitor of the binding of concanavalin A. Concanavalin A prevented both patch and cap formation, in contrast to the metabolic inhibitor NaN(3), which prevented only cap formation. This suggests that binding of concanavalin A induces changes on or in the lymphocyte membrane that inhibit free diffusion of immunoglobulin receptors.
    [Abstract] [Full Text] [Related] [New Search]