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  • Title: Reduction of the renal toxicity of cis-dichlorodiammineplatinum(II) by probenecid.
    Author: Ross DA, Gale GR.
    Journal: Cancer Treat Rep; 1979 May; 63(5):781-7. PubMed ID: 455315.
    Abstract:
    Probenecid, when administered sc to F344 rats 1 hour prior to an iv LD50 dose of cis-dichlorodiammineplatinum(II) (CDPP), reduced significantly the peak BUN and serum creatinine levels which occurred 4 days following CDDP. Renal histopathology was similarly reduced by probenecid pretreatment. In BDF, mice, the LD50 value of CDDP administered ip without probenecid pretreatment was 17 mg/kg; the LD50 dose with probenecid was increased to greater than 19 mg/kg. Probenecid pretreatment did not influence the therapeutic response to CDDP when the letter was administered to BDF mice bearing L1210 leukemia.
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