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  • Title: Plasma renin activity during the development of paracetamol (acetaminophen) induced acute renal failure in man.
    Author: Wilkinson R, James OF, Roberts SH, Morley AR, Robson V.
    Journal: Clin Nephrol; 1979 Apr; 11(4):196-201. PubMed ID: 455818.
    Abstract:
    Plasma renin activity has been measured daily in 36 patients suffering from self poisoning with acetaminophen. In 3 developing porto-systemic encephalopathy terminal renal failure developed with high plasma renin activity. In 2 who developed acute renal failure without porto-systemic encephalopathy, plasma renin activity was noted to rise before serum creatinine and to return to initial levels after 3 or 4 days while renal failure persisted. Six other patients with similar hepatic damage showed comparable rises in renin without developing renal failure. Our findings are consistent with but do not establish a pathogenetic role for renin in acetaminophen-induced acute renal failure. It is suggested that other factors may act with renin to bring about renal failure.
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