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  • Title: Comparison of the cardiovascular toxicity of three tricyclic antidepressant drugs: imipramine, amitriptyline, and doxepin.
    Author: Brown TC, Leversha A.
    Journal: Clin Toxicol; 1979 Mar; 14(3):253-6. PubMed ID: 455914.
    Abstract:
    Experiments were conducted on puppies to compare the cardiovascular toxicity of imipramine, amitriptyline, and doxepin. The drugs were infused at weekly intervals to produce arrhythmias and/or hypotension. Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin.
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