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  • Title: Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes.
    Author: Mangkornkanok M, Markowitz AS, Battifora HA.
    Journal: Science; 1972 Oct 20; 178(4058):316-8. PubMed ID: 4562254.
    Abstract:
    Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.
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