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  • Title: A new element in the control of DNA initiation in Escherichia coli.
    Author: Blau S, Mordoh J.
    Journal: Proc Natl Acad Sci U S A; 1972 Oct; 69(10):2895-8. PubMed ID: 4562745.
    Abstract:
    When a thermosensitive mutant of E. coli affected in DNA initiation is heated to 41 degrees , a protein needed for DNA initiation is irreversibly denatured. When these bacteria are incubated at 30 degrees in the presence of several concentrations of chloramphenicol, DNA synthesis is greatly stimulated at a chloramphenicol, DNA synthesis is greatly stimulated at a chloramphenicol concentration of 2.5 mug/ml, and then sharply decreases. This stimulation of DNA synthesis appears to be caused by an increased frequency of initiation. The existence of an "anti-initiator" protein controlling the frequency of chromosomal initiation is proposed.
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