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  • Title: Difference in the target cells for tolerance induction in relation to the dose of tolerogen.
    Author: Katsura Y, Kawaguchi S, Muramatsu S.
    Journal: Immunology; 1972 Oct; 23(4):537-44. PubMed ID: 4563476.
    Abstract:
    Bone marrow cells and thymus cells were observed in cell transfer experiments to collaborate in the production of anti-BSA antibodies. The target cells for tolerance induction either with a `low dose' of antigen (100 μg of deaggregated BSA once a week × 5) or with a `high dose' (a single injection of 5000 μg) were identified by the same technique. In `low dose' tolerance, some indication was obtained that thymus-derived cells in peripheral lymphoid systems were the target cells; bone marrow-derived cells appeared not to be so susceptible, and the cells residing in thymus or bone marrow seemed to remain unimpaired. In contrast, the injection of a `high dose' of tolerogen rendered both types of cells in spleen, thymus cells and bone marrow cells, unresponsive or hyporesponsive in parallel with one another.
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