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  • Title: DNA modification methylase activity of Escherichia coli restriction endonucleases K and P.
    Author: Haberman A, Heywood J, Meselson M.
    Journal: Proc Natl Acad Sci U S A; 1972 Nov; 69(11):3138-41. PubMed ID: 4564204.
    Abstract:
    The highly purified restriction endonucleases of E. coli K and coliphage P1 transfer methyl groups from S-adenosylmethionine to adenine residues of unmodified DNA. Incubation of unmodified DNA with endonucleases K or P and S-adenosylmethionine renders the DNA resistant to restriction. The enzymes, therefore, have both restriction endonuclease and modification methylase activities.
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