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  • Title: Mianserin potentiates responses to acetylcholine in the rat anococcygeus muscle.
    Author: Doggrell SA.
    Journal: Eur J Pharmacol; 1979 May 01; 55(3):311-4. PubMed ID: 456428.
    Abstract:
    In the rat anococcygeus muscle, mianserin (1 and 10 muM) increased the magnitude of the maximal contractile responses to acetylcholine and carbamylcholine without affecting the maximal responses to (--)-noradrenaline. The potentiating effect of mianserin on responses to acetylcholine was maintained in the presence of 5muM phentolamine, following 6-hydroxy dopamine incubation of the tissues (1 mM for 3h) and in the presence of 1 muM nortriptyline. It is suggested that mianserin increases the sensitivity to acetylcholine by an action at the level of, or distal to, the cholinergic receptor.
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