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  • Title: 18-Hydroxy-11-deoxycorticosterone in hypertensive uremic patients during hemodialysis.
    Author: Sparano F, Giaquinto G, Odoardi A, Mercuri MA, Tosti-Croce C, Sulon J, Sciarra F.
    Journal: Horm Res; 1979; 10(5):282-8. PubMed ID: 457038.
    Abstract:
    The present study was carried out in 25 hypertensive uremic patients on regular 4 h dialysis, 3 times a week. Plasma 18-hydroxy-11-deoxycorticosterone (18-OH-DOC), aldosterone (PA) and corticosteroids were determined by radioimmunoassay and competitive protein binding technique before and at the end of the 1st, 2nd and 3rd hour of hemodialysis. Plasma 18-HD-DOC was normal before dialysis and did not change significantly during hemodialysis, whereas body fluids and electolytes decreased progressively. No correlation was observed between blood pressure and 18-OH-DOC during dialysis. 18-OH-DOC did not correlate with PA which decreases progressively during hemodialysis and was correlated to plasma corticosteroids only at the 3rd hour of dialysis, probably on account of the enhanced influence of ACTH on the adrenal cortex.
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