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  • Title: Copper determination and localization in different morphologic components of human endometrium during the menstrual cycle in copper intrauterine contraceptive device wearers.
    Author: Salaverry G, Méndez Mdel C, Zipper J, Medel M.
    Journal: Am J Obstet Gynecol; 1973 Jan 15; 115(2):163-8. PubMed ID: 4570954.
    Abstract:
    Comparisons were made of endometrial biopsies performed at random during the 4 phases of the menstrual cycle and after different periods of use on women wearing TCU-120 sq.mm IUD devices, users of plain T devices (minus Cu), and patients without IUDs to determine the localization of Cu delivered by the IUD and the leukocytic infiltration rate. Cu was found to localize in the secretory vacuoles of the endometrial epithelial cells during the progestational phase and was absent during the estrogenic phase indicating that a rise in Cu concentration is progesterone-dependent. No Cu was detected 7 or more days after extraction of the device. No increase in leukocytic infiltration was found in TCU-120 sq.mm device wearers suggesting that the contraceptive mechanism of Cu is not related to leukocyte concentration.
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