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  • Title: Differentiation of lens tissue from the progeny of chick retinal pigment cells cultured in vitro: a demonstration of a switch of cell types in clonal cell culture.
    Author: Eguchi G, Okada TS.
    Journal: Proc Natl Acad Sci U S A; 1973 May; 70(5):1495-9. PubMed ID: 4576021.
    Abstract:
    Clonal cell lines isolated from the pigmented retina of 8.5-day chick embryos initially retained the capacity to form pigment. After several passages, however, many cells lost pigment granules and differentiated into lens-like structures. The lens-specific nature of the structures formed in cultures originally derived from retinal pigment cells was established by both ultrastructural and immunological studies.
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