These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect in mice of injection of viable Candida albicans and a cell-free sonic extract on circulating platelets.
    Author: Holder IA, Nathan P.
    Journal: Infect Immun; 1973 Mar; 7(3):468-72. PubMed ID: 4576682.
    Abstract:
    The ability of intravenously injected Candida albicans to cause thrombocytopenia and clotting disorders was tested. Mice injected in this manner showed a decrease in circulating platelets and a shortening of clotting time within hours after challenge. Treatment with heparin changed the death distribution pattern, but did not increase overall long-term survival. A cell-free sonic extract prepared from viable C. albicans cells was shown to cause aggregation of platelets in vitro, and injection of the cell-free extract into mice caused a decrease in circulating platelets similar to that observed when viable organisms were injected.
    [Abstract] [Full Text] [Related] [New Search]