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  • Title: Tiapride in levodopa-induced involuntary movements.
    Author: Lees AJ, Lander CM, Stern GM.
    Journal: J Neurol Neurosurg Psychiatry; 1979 Apr; 42(4):380-3. PubMed ID: 458486.
    Abstract:
    Tiapride, a substituted benzamide derivative closely related to metoclopramide, reduced levodopa-induced peak dose involuntary movements in 16 patients with idiopathic Parkinson's disease. However, an unacceptable increase in disability from Parkinsonism with aggravation of end-of-dose akinesia led to its cessation in 14 patients. Tiapride had no effect on levodopa-induced early morning of "off-period" segmental dystonia. These results fail to support the notion that levodopa-induced dyskinesias are caused by overstimulation of a separate group of dopamine receptors.
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