These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Selective membrane toxicity of the polyene antibiotics: studies on natural membranes.
    Author: Hsuchen CC, Feingold DS.
    Journal: Antimicrob Agents Chemother; 1973 Sep; 4(3):316-9. PubMed ID: 4586145.
    Abstract:
    The effect of polyene antibiotics on Candida albicans, human erythrocytes, and Acholeplasma laidlawii was studied. The results sustain the observations made with lecithin-sterol liposomes. The distribution of double bonds in the membrane sterol nucleus appears to be of major importance in conferring polyene susceptibility; those sterols with the ergosterol nucleus are far more effective than those with a nucleus similar to cholesterol. Different polyenes vary in their membrane selectivity. The clinical implications of these observations are discussed.
    [Abstract] [Full Text] [Related] [New Search]